The fastest route from Amsterdam to Istanbul is by flight, taking approximately 300 minutes. If saving time is your priority, this is the clear choice. However, consider the price range of 80 to 350 USD, which varies based on booking timing and provider.
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Cheapest
The cheapest option is to secure a ticket around 80 USD, though prices vary. Planning ahead can help save on costs.
For families
For families seeking comfort and speed, the flight is the best option. The relatively short flight duration reduces the strain on children.