The fastest way from Istanbul to Berlin is by flight, taking approximately 300 minutes. Prices range from 80 to 350 USD, so you'll need to see what fits your budget. If time is a major factor, flying is the way to go.
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Cheapest
If budget is your main concern, look for the lower-priced flights. Keep in mind that cheaper flights might include layovers or be less comfortable.
For families
For families, a direct flight might be the most convenient despite the cost. It offers shorter travel time and less hassle.