The fastest way to travel from Mexico City to Guadalajara is by flight, taking approximately 300 minutes. If speed is your priority, flying is the best option. However, be aware of the costs, which range from 80 to 350 USD.
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Cheapest
The flight option is not particularly cheap, but it is the fastest. If you're looking to save money, no other options were provided.
For families
Flying suits families seeking comfort and speed, though costs may be high depending on the number of travelers.