Flying from Lisbon to Barcelona is the fastest option, taking 300 minutes. If time is your priority, this is the clear choice. However, be mindful of the price range, which can vary from 80 to 350 USD.
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Cheapest
While the flight is the fastest option, the prices can be steep, so it's wise to check the fares in advance.
For families
For families, the flight offers convenience and speed, but consider the total cost for multiple tickets.